Table 3 Positively selected sites in the human, chimpanzee and gorilla lineages.

From: Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders

Gene

Lineage

Codon

Ancestral AA

Derived AA

Pra

GORASP2

Human

257

Ala

Thr

0.901

Gorilla

247

Pro

Ser

0.988

HSPA4

Human

778

Ile

Thr

0.982

MDM2

Human

283

Arg

Gln

0.960

Human

432

Met

Val

0.961

Gorilla

413

Ser

Cys

0.948

MYC

Human

369

Asp

Val

0.874

Chimp

224

Ala

Pro

0.872

PSMA7

Human

216

Pro

Ser

0.911

RAB2A

Gorilla

197

Thr

Ser

0.752

RB1

Human

233

Val

Met

0.947

SETD5

Chimp

421

Thr

Ala

0.759

Chimp

563

Pro

Ala

0.760

SMARCC1

Human

117

Thr

Ala

0.850

Human

437

Pro

Leu

0.851

SYT1

Gorilla

420

Val

Ile

0.902

TRAF2

Human

237

Ala

Val

0.963

Human

258

Ser

Leu

0.963

Human

373

Thr

Ile

0.935

Gorilla

221

Ile

Val

0.781

UIMC1

Chimp

429

Arg

Gly

0.958

Chimp

439

Ala

Thr

0.960

Chimp

511

Arg

His

0.911

Chimp

597

Ser

Gly

0.974

Chimp

601

Cys

Phe

0.974

Gorilla

16

Asn

Ile

0.913

Gorilla

62

Thr

Ala

0.894

Gorilla

502

Gln

His

0.764

Gorilla

581

Ser

Cys

0.775

  1. aPosterior probability of γ ≥ 1 as detected by gammaMap.