Figure 1

Antibiotic treatment schedule, strain isolation dates, and in-vitro strain selection. Phenotypic and genotypic characteristics of the strains are indicated, as well as the selection frequency of the in-vitro mutants. Red indicates carbapenem-resistant strains and green indicates strains susceptible to at least one carbapenem. R: resistant; S: susceptible; Carba: carbapenems; FOX: cefoxitin; ERT: ertapenem; IMI: imipenem; TIG: tigecycline.