Figure 3
From: Novel risk genes for systemic lupus erythematosus predicted by random forest classification
Over-representation of genes with allele-specific expression (ASE) in disease associated genes. Fold difference of expressed predicted SLE genes and autoimmunity associated genes with ASE in more than 80% of the individuals compared to all other genes. The risk genes in T-cells were significantly overrepresented in all gene sets, with the top 40 genes from random forest classification (p = 0.0079), top 40 genes from logistic regression (p = 0.015), and autoimmunity associated genes (p < 0.0001). Additionally, the enrichment of the autoimmunity associated risk genes in B-cells was also significant (p = 0.007).
