Table 2 Putative dominant loss-of-function candidate genes where at least one sample had a rare protein disruptive variant in the suicide samples.

From: High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder

GENE

CHR

POS

REF

ALT

CONSEQUENCE

SAMPLE ID

MRPL45*

17

36478478

A

C

stop-loss

BrA206,Y426

CACNA2D4

12

2024019

C

A

splice donor & intron

Y516

OTOGL

12

80764471

T

C

splice donor & intron

Y591

CWC27

5

64084836

C

T

stop-gain

Y520

SPATA31C2*

9

90748568

T

A

splice acceptor & intron

Y558

RGL4*

22

24041028

CAGCTACAAGCTGT

C

splice acceptor & splice region & intron & non-coding transcript exon

Y331

PMCH

12

102591506

AAGTT

A

frameshift

Y532

TRIM15*

6

30131613

CG

C

frameshift

Br333

CEP85L

6

118880200

T

G

stop-gain

Y166

NME1

17

49231585

G

C

splice acceptor & intron

Y166

ZNF718*

4

60294

T

C

stop-loss & splice region

Y375

CENPC

4

68385221

C

G

splice acceptor & intron

Y724

CDK14*

7

90338857

T

C

start-loss

Y591

RAB3GAP2

1

220363490

T

C

splice acceptor & intron

Y292

PMM2

16

8900171

A

G

splice acceptor & intron

Y375

TMPRSS11F*

4

68919659

G

A

stop-gain

Y919

SURF4*

9

136233553

T

A

splice acceptor & intron

Y482

CKB

14

103988441

G

A

stop-gain

Y919

PCYOX1L*

5

148742545

CAA

C

frameshift

Y532

MIXL1

1

226413300

T

A

stop-gain

Y516

D2HGDH

2

242688420

CCCTGTGAGGATGGT

C

splice donor & splice region & intron

Y724

PSKH1*

16

67961717

C

T

splice acceptor & intron

Y316

BRMS1L

14

36333074

A

G

splice acceptor & intron

Y919

ST14

11

130058476

AT

A

frameshift

Y591

STRA8*

7

134925307

CA

C

frameshift

Y919

ARRDC2*

19

18120687

C

T

stop-gain

Y292

BOD1L1*

4

13629016

GC

G

frameshift

Y292

H2AFZ*

4

100871387

T

C

splice donor & intron

Y426

CFAP70*

10

75056798

A

G

splice donor & intron

Y166

SKOR2*

18

44746383

T

C

splice acceptor & intron

Y558

PRKAG2

7

151573704

A

G

start-loss

Y316

ADRA1A

8

26636945

C

A

stop-gain & splice region

Y516

TMEM132C*

12

129189800

G

T

stop gain

Y421

S100A13*

1

153600595

A

AC

splice donor & intron

Y724

DLG2

11

83191415

G

A

stop-gain & splice region

Y331

PCSK5

9

78790138

AAATGGAATGGAATGAAATGGAATGGAATGGAATGG

A

frameshift

Y421

C1orf226*

1

162353052

CCA

C

frameshift

Y426

EPS15

1

51946947

GTC

G

frameshift

Y482

WDR12*

2

203749260

T

C

splice acceptor & intron

Y375

TMA16*

4

164415989

G

A

splice donor & intron

Y645

LOC100507443*

2

208993176

C

CA

frameshift

Y516

CES4A*

16

67035297

TC

T

frameshift

Y558

NUDCD3*

7

44530037

G

GCT

frameshift

Y724

TP53RK

20

45315393

T

C

stop-loss

Y331

RABGGTA

14

24737761

C

T

stop-gain

Y919

UBE2E3*

2

181846846

AC

A

frameshift

Y166

MPDZ

9

13140066

A

G

start-loss

Br857

TNFRSF11B

8

119936822

G

A

stop-gain

Y919

ABI1

10

27054244

TC

T

frameshift & splice region

Y919

HAPLN1

5

82940440

TGA

T

frameshift

BrA206

MRAP2

6

84772679

C

CT

frameshift

Y591

CAND2*

3

12854548

G

T

stop-gain

Y393

CACNA1C

12

2659708

A

C

splice acceptor & intron

Y988

KRTAP2-4*

17

39221826

G

GA

frameshift

BrA206

SORL1

11

121502724

G

C

splice acceptor & intron

Y520

LRRC37A4P*

17

43585907

T

C

splice acceptor & intron

Y482

PEMT

17

17409148

T

G

stop-loss

Y645

RBMXL2

11

7110854

GC

G

frameshift

Br333

ZNF646*

16

31091705

C

T

stop-gain

Br857

RBM12B*

8

94752787

T

A

stop-loss

Y787

TGIF2LY*

Y

3447816

GCC

G

frameshift

Y645

  1. Each genetic variant was a heterozygote. GENE is the name of gene; CHR and POS shows the GRCh37 coordinate of the variant, REF/ALT columns shows the reference and alternate alleles, CONSEQUENCE is the type of the protein disruption, and the SAMPLE ID column contains the sample names in which the given variant was found.
  2. *denotes genes without disease association in MalaCards and OMIM.
Back to article page