Figure 2
From: The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Structural analyses of mTnfaip8. (a) The superimposed crystal structure of mTnfaip8 (green) with that of hTIPE2 (gold; PDB ID: 3F4M) and hTIPE3 (sky blue; 4Q9V) are shown. The entrance of the cavity is highlighted in the solid box. The starting N-terminal residues are labeled according to their ribbon colors. The zoomed view represents the binding mode of PE in the highlighted region. (b) The hydrophobic cavity of mTnfaip8 with PE. (c) The composite omit map (upper) and the 2Fo-Fc electron density map (lower), contoured at the 0.9 σ level, for the region of PE are shown in blue mesh.
