Table 1 Physicochemical Data, MW, and log D (octanol/water, pH 7.4), and Caco-2 permeability for the three tested drugs (from refs 1, 15 and 48).
Compound | Propranolol | Metoprolol | Atenolol |
|---|---|---|---|
Molecular weight (g/mol) | 259.35 | 267.37 | 266.34 |
LogD (7.4) | 1.45 | −0.287 | −1.51 |
Caco-2 Papp (1E-6.cm/s) | 41.9 | 27.0 | 0.20 |
Ion Class | Base | Base | Base |
Structure |
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