Figure 1

(a) Major gene products of T7 phage genome and domain architecture of T7RNAP with major sub-domains; (b) T7RNAP model structure: The color representation is as follows, the N-terminal domain (1–325), yellow; the thumb (326–411), green; the palm (412–449, 528–553, 785–879), dark blue; the palm insertion module (450–527), light blue; the fingers (554–739, 769–784), orange; specificity loop (740–769), pink; extended foot module (838–879), cyan; and C-terminal (880–883), violet. Two metal ions at the active site are shown as green spheres.