Figure 1 | Scientific Reports

Figure 1

From: β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes

Figure 1

Schematic of the 2-dimensional topology of the human β1AR. The single N-glycosylation site in the N-terminus at position 15, in a consensus sequence [Nx(S/T)] is shown in blue. Putative O-glycosylation consensus sites (Ser residues in a Pro-rich environment) examined in this study are shown in red; the Ser49Gly polymorphism maps to a putative O-glycosylation site. Cleavage sites previously identified at the β1AR N-terminus are shown in turquoise13; cleavage at P52-L53 generates a non-glycosylated receptor. Constructs used for the experiments depicted in Figs 2, 3 and 6 contained N-terminal FLAG (DYKDDDDK) and C-terminal HA (YPYDVPDYA) tags.

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