Figure 1 | Scientific Reports

Figure 1

From: Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model

Figure 1

Histological views of ASCC in Tgfbr1/Pten 2cKO mice. (a) A representative sagittal section of mice ASCC. Scale bar = 1 cm (b,c) High-power fields of the tumor margins. Tumor islands were extended into underlying tissue with well-defined invasive front and accompanied by stromal reaction. Distinct nuclear pleomorphism was seen. Scale bar = 50 μm. (d) Another representative sagittal section of mice ASCC. Scale bar = 1 cm (e,f) High-power fields of the tumors showing tumor cords invaded into the muscle layer. Nebulous infiltrating margins and discontinuous basal layers were seen. Cancer cells were forming irregular small strands or cords with poor keratinization. Densely infiltrating lymphocytes were seen. Scale bar = 50 μm.

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