Figure 3 | Scientific Reports

Figure 3

From: Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model

Figure 3

S3I-201 treatment protected mice from tumor challenge. (a) A schematic flow chart showed the drug delivery strategy of S3I-201 in the chemopreventive tumorigenesis experiment in Tgfbr1/Pten 2cKO mice. (b) Pictures of visible tumors were photographed at day 35 and day 56 in control group and S3I-201 chemopreventive group. The number of mice with ASCC (c) or the average sizes of tumor (d) were significantly reduced after S3I-201 treatment. And mice in the S3I-201 treatment group did not suffer from extra body weight loss (e), which is an indicator of drug toxicity. **P < 0.01; ***P < 0.001.

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