Figure 2

Separation between EC and naive patients in inter-individual (ß-diversity) analyses. Non-metric multidimensional scaling (NMDS) analysis was performed to characterize inter-individual differences between groups, revealing clustering of EC at NMDS axis 1 and naive at axis 2. The separations between groups at each axis are presented in respective box-plot. Box plots represent median (black horizontal line), 25th and 75th quartiles (edge of boxes), upper and lower extremes (whiskers). Outliers are represented by a single data point (a). LASSO regression analysis with AUROC (ROC curves; AUC used for estimation of model accuracy) curve was used for classification of gut microbiota composition between groups, and lowest accuracy was found between EC and negative patients (AUC 0.77, suggesting that the similarity of microbiota composition was highest between these groups) (b).