Table 2 Soluble markers of inflammation and metabolites of kynurenine/tryptophan catabolism in plasma.
From: Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
EC | Naive | Negative | p-value* | |
|---|---|---|---|---|
Soluble marker: median(IQR) | ||||
LBP (ng/ml) | 3727 (2206–15123) | 6805 (5984–8031) | 2862 (1956–3705) | 0.0004 |
sCD14 (pg/ml) | 1.7 × 106 (1.53–1.95 × 106) | 1.47 × 106 (1.46–1.71 × 106) | 1.5 × 106 (1.44–1.65 × 106) | ns |
IL-6 (pg/ml) | 1.73 (1.18–3.20) | NA | 0.84 (0.67–1.78) | 0.035 |
hs-CRP (pg/ml) | 1.37 × 106 (0.76–2.7 × 106) | NA | 635419 (378718–941463) | 0.005 |
Tryptophan catabolism: | ||||
Tryptophan (umol/L) | 53.1 (51.4–60.5) | 46.2 (40.5–50.8) | 66.1 (60.3–73.1) | <0.0001 |
Kynurenine (umol/L) | 1.4 (1.3–1.6) | 1.65 (1.3–2) | 1.7 (1.4–1.9) | ns |
Anthralinic acid (nmol/L) | 12.2 (10.1–16.2) | 21.6 (16.3–28.8) | 15.3 (11.6–20.6) | 0.0007 |
Kynurenic acid (nmol/L) | 40.5 (36.2–50.6) | 30.3 (17.6–48.9) | 54.2 (48.9–70.2) | 0.0015 |
3-Hydroxykunrenin (nmol/L) | 45.9 (33.8–59.6) | 35.1 (29.5–48.7) | 41.9 (33.1–53.1) | ns |
Xanthurenic acid (nmol/L) | 11.8 (8.4–19.5) | 9.2 (3.4–14.5) | 19.9 (15–27.8) | 0.0013 |
3-Hydroxyantralinic acid (nmol/L) | 27.2 (22.5–35.5) | 31.6 (20–47.7) | 31.5 (23.4–41.1) | ns |
Quinilonic acid (nmol/L) | 349 (262.3–448.5) | 474.4 (352.2–669.2) | 359 (304–425) | 0.039 |
K/T ratio | 24.8 (21.2–30.8) | 34.8 (31.2–46.9) | 24.6 (20.8–28.9) | 0.0001 |
