Figure 4
Methylatropine (MA) and Propranolol (Prop) administration abrogates the anti-inflammatory effect of electrical stimulation of the carotid sinus nerve (CSN) on plasma cytokines concentration in LPS induced systemic inflammation in conscious rats. Panel a: TNF (**p = 0.02 vs Control) 1 hour after LPS and MA administration. Panels b, c, and d, respectively: IL-6 (**p = 0.007 vs Control), IL-1β (**p = 0.002 vs Control) and IL-10 (**p = 0.01 vs Control) at 3 hours after LPS and MA administration. Panel e: TNF(**p = 0.009 vs Control) 1 hour after LPS and Prop administration. Panels f, g, and h, respectively: IL-6 (**p < 0.001 vs Control), IL-1β (**p < 0.001 vs Control), and IL-10 (**p = 0.04 vs Control) at 3 hours after LPS and Prop administration. Number of animals is shown between parentheses.
