Figure 5 | Scientific Reports

Figure 5

From: Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF

Figure 5

Neutrophils (A and C) and white blood cells (B and D) counts in neutropenic rats received single injection of GCSF-Fc, PEG-GCSF and GCSF. On day 0, 5 rats in each group but the control group received 100 mg/kg CPA to induce neutropenia. On day 1, neutropenic groups received injections of PBS, GCSF (100 µg/kg), PEG-GCSF (100 µg/kg), or GCSF-Fc (50 µg/kg, 100 µg/kg and 300 µg/kg). Blood samples from the rat groups over 12 days were sent for complete blood count (CBC) analysis. Data are means ± SE of 5 rats/group. Statistical significance compared to GCSF treatment group: *p < 0.05, **p < 0.01.

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