Figure 2 | Scientific Reports

Figure 2

From: Phenothiazines Enhance Mild Hypothermia-induced Neuroprotection via PI3K/Akt Regulation in Experimental Stroke

Figure 2

Infarct volume reduction by combination therapy of mild hypothermia and C + P. (a) TTC histology demonstrating infarct volume reduction in the penumbra region of ischemic territory supplied by MCA with mild hypothermia (S&H), C + P (S&D), combination therapy (S&HD), and combination therapy + p-Akt inhibitor (LY294002) (S&HD&LY). (b) Percentage of infarct volume reduction (Mean ± SD) with mild hypothermia (S&H), C + P (S&D), combination therapy (S&HD), and combination therapy +p-Akt inhibitor (LY294002) (S&HD&LY). Combination therapy largely and significantly reduced the infarct volume, and treatment with LY294002 reversed the combination therapy’s neuroprotective effect, implicating a role in the PI3K/Akt signaling pathway. **P < 0.01, n = 7 per group.

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