Figure 1

Evaluation of chronically diseased tissue and adjacent tissue obtained from the sigmoid colon of chronic, recurrent diverticulitis patients. (A) Illustrated representation of the sigmoid colon with areas obtained for analysis shown in boxes. Chronically diseased tissue (DT) is an area of thickened bowel wall. Adjacent tissue (AT) is an area of normal bowel wall thickness. Diverticulae may be present in either tissue section. (B) Sigmoid colon taken from a patient immediately after resection and representative tissue sections shown in boxes. (C) Representative H&E stained section from AT shows minimal mucosal neutrophilic inflammation. (D) Higher magnification of the boxed area of (C) showing negligible mucosal inflammation. (E) Representative H&E stained section from DT with minimal mucosal inflammation demonstrated by the presence of few mucosal neutrophils within the lamina propria. (F) Higher magnification of the boxed area of (E) with neutrophils marked by an arrow.