Figure 3 | Scientific Reports

Figure 3

From: The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

Figure 3

Differential bacterial and archaeal compositions comprise chronically diseased tissue and adjacent tissue. (A) LDA Effect Size (LEfSe) plot of taxonomic biomarkers identified within chronically diseased tissue (DT) and adjacent tissue (AT) samples. Red bars are indicative of enrichment within DT samples, whereas green bars are indicative of enrichment within AT samples. A Kruskal-Wallis test was employed at an alpha = 0.05 to identify significantly enriched taxa, whereas a pairwise Wilcoxon rank sum test was utilized to test biological consistency across all subgroups (alpha = 0.05). A linear discriminant analysis (LDA) was calculated to determine effect size and we present all taxa that yielded an LDA score >1.5. A total of 33 taxa (25 being taxonomically identified) were found to be enriched in both sample groupings. (B) PICRUSt-inferred metagenomics and LEfSe predicted-function enrichment plots. Functions with an LDA score >1.5 are shown. Inferred molecular function of the bacterial populations identified by 16S rRNA gene sequencing are stratified by tissue type (chronically diseased tissue (DT) and adjacent tissue (AT).

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