Figure 4

Uremia does not affect neointima formation in carotid arteries after vascular injury in Apoe ^−/− mice. (A) Study outline: Apoe ^−/− mice underwent 5/6 nephrectomy (NX) or sham operation (sham) in two steps (timepoints NX1 and NX2), were put on a western diet, and subsequently underwent carotid wire injury. B. Representative pictures of Trichrome stained injured carotid arteries from NX and sham Apoe ^−/− mice. Scale bar, 200 μm. (C) Histological quantification of cross-sectional intimal and (D) medial area in injured carotid arteries from NX and sham Apoe ^−/− mice (average of 8–12 sections per mouse; n = 16 NX, n = 7 sham), four weeks after wire injury. Horizontal bars represent mean values. Upaired t-test.