Figure 4
Gene ablation of Sirt1 or AMPKα2 augments mast cell-mediated anaphylaxis. IgE/Ag-induced PCA reactions in WT, mast cell-specific Sirt1 −/− (KO) (a) or AMPKα2 −/− (KO) (b) mice were evaluated in the presence or absence of REV. The amounts of evans blue exudation are presented (n = 7 mice per group; #P < 0.05, ##P < 0.01 vs. DNP-HSA alone in either WT or KO group; **P < 0.01, ***P < 0.001 vs. WT for each treatment). Top panels show representative photos of ears with dye extravasation at 1 h.
