Figure 2

Mean global DNAm differences and naïve T-cell subtype differences between groups. (a) Patients (T1) showed significantly decreased mean global DNAm levels compared to controls (P = 0.048, Mann-Whitney U test). Differences between controls vs. patients (T2) and patients (T1) vs. patients (T2) were not significant. (b) Abundance levels of naïve CD8⁺ and CD4⁺ T-cells were predicted using an advanced blood DNA methylation age prediction tool. Both naïve T-cell subtypes significantly increased post-treatment in patients (**Indicates an FDR < 0.01, Wilcoxon signed-rank test) but were not significantly different between controls and patients at either time point.