Table 1 Characteristics of the included studies.
First author/Publication year | Region | Stroke subtype | Study design | Characteristics of populations and interventions | Main outcomes | |
|---|---|---|---|---|---|---|
Very early mobilization | Late mobilization | |||||
Herisson 201618 | France | Ischemic stroke | RCT | Age (mean): 68.1 y; SS (n): 63; MT: begin within 24 h of stroke onset; OOB activity: sitting | Age (mean): 71.2 y; SS (n): 75; MT: begin after 24 h of stroke onset; OOB activity: sitting | mRS, mortality, NIHSS, Barthel Index, and medical complications at 3 months, length of hospital stay |
Chippala 201619 | India | Any stroke | RCT | Age (mean): 59.3 y; SS (n): 40; MT: begin within 24 h of stroke onset; OOB activity: sitting, standing, and walking | Age (mean): 60.6 y; SS (n): 40; MT: begin after 24 h of stroke onset; OOB activity: sitting, standing, and walking | Barthel Index at 3 months, length of hospital stay |
Poletto 20155 | Brazil | Ischemic stroke | RCT | Age (mean): 64.0 y; SS (n): 18; MT: begin within 48 h of stroke onset; OOB activity: sitting, standing, and walking | Age (mean): 66.0 y; SS(n): 19; MT: begin after 48 h of stroke onset; OOB activity: sitting, standing, and walking | mRS, Barthel Index at 3 months, length of hospital stay |
Bernhardt 2015 (AVERT III)15 | Australia, New Zealand, Malaysia, Singapore, and UK | Any stroke | RCT | Age (median): 72.3 y; SS (n): 1,054; MT: begin within 24 h of stroke onset; OOB activity: sitting, standing, and walking | Age (median): 72.7 y; SS (n): 1,050; MT: begin after 24 h of stroke onset; OOB activity: sitting, standing, and walking | mRS, mortality, and medical complications at 3 months, length of hospital stay |
Liu 201420 | China | Hemorrhagic stroke | RCT | Age (mean): 58.5 y; SS (n): 122; MT: begin within 48 h of stroke onset; OOB activity: exercises and functional training | Age (mean): 59.1 y; SS (n): 121; MT: begin after 7 d of stroke onset; OOB activity: exercises and functional training | Mortality and Barthel Index at 3 months, length of hospital stay |
Sundseth 201216 | Norway | Any stroke | RCT | Age (mean): 76.5 y; SS (n): 27; MT: begin within 24 h of stroke onset; OOB activity: NA | Age (mean): 77.3 y; SS (n): 29; MT: begin after 24 h of stroke onset; OOB activity: NA | mRS, mortality, Barthel Index, NIHSS, and medical complications at 3 months |
Diserens 201221 | Switzerland | Ischemic stroke | RCT | Age (mean): 72.0 y; SS (n): 25; MT: begin at 52 h of stroke onset; OOB activity: sitting, standing, and walking | Age (mean): 71.0 y; SS (n): 17; MT: begin after 7 d of stroke onset; OOB activity: sitting, standing, and walking | mRS, mortality, and medical complications at 3 months, length of hospital stay |
Langhorne 2010 (VERITAS)22 | Australia and UK | Any stroke | RCT | Age (median): 64.0 y; SS (n): 16; MT: begin within 24 h of stroke onset; OOB activity: sitting, standing, and walking | Age (median): 71.0 y; SS (n): 16; MT: begin after 24 h of stroke onset; OOB activity: sitting, standing, and walking | mRS, mortality, Barthel Index, and medical complications at 3 months, length of hospital stay |
Bernhardt 2008 (AVERT II)6 | Australia | Any stroke | RCT | Age (median): 74.6 y; SS (n): 38; MT: begin within 24 h of stroke onset; OOB activity: sitting, standing, and walking | Age (median): 74.9 y; SS (n): 33; MT: begin after 24 h of stroke onset; OOB activity: sitting, standing, and walking | mRS, mortality, and medical complications at 3 months, length of hospital stay |
