Table 2 Epidemiology and virulence profiles of Klebsiella pneumoniae isolates from CSF of post-craniotomy and primary meningitis.
From: Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance
CSF Strains | PFGE | MLST | ESBL | AmpC | Virulence factors | LD50 (log) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bacterial size (μm) | HV (mm) | Capsule K | rmpA | rmpA2 | c-rmpA | Kfu | allS | aerobactin | SR | ||||||
Post-craniotomy meningitis (n = 13) | |||||||||||||||
KP-004a | A | 17 | − | CMY-2 | 1.11 ± 0.21 | <0.5 | x | − | − | − | − | − | − | G2 | >6.50 |
KP1050b | O | 107 | SHV-5 | − | 1.42 ± 0.16 | <0.5 | x | − | − | − | + | − | − | G6 | >6.84 |
KP1051b | H1 | 17 | SHV-5 | − | 1.44 ± 0.11 | <0.5 | x | − | − | − | − | − | − | G2 | >6.72 |
KP1052b | N1 | 15 | SHV-5 | DHA-1 | 1.72 ± 0.07 | <0.5 | x | − | − | − | − | − | − | G6 | >6.42 |
KP1053b | G | 54 | SHV-5 | − | 1.28 ± 0.15 | <0.5 | x | − | − | − | − | − | − | G6 | >6.55 |
KP1054b | I1 | 86 | SHV-5 | − | 2.98 ± 0.41 | <0.5 | 2 | + | + | − | − | − | + | G5 | >6.88 |
KP-042c | unidentified | 185 | − | DHA-1 | 1.31 ± 0.18 | <0.5 | x | − | − | − | − | − | − | G4 | >6.52 |
KP-023c | D | undefined | TEM-1B | CMY-2 | 0.92 ± 0.16 | <0.5 | x | − | − | − | + | − | − | G3 | >6.36 |
KP-201c | E2 | 65 | SHV-5 | − | 4.62 ± 0.65 | >2 | 2 | + | + | − | − | − | + | G6 | 4.13 |
KP-001a | J1 | 373 | − | − | 4.66 ± 0.66 | >2 | 2 | + | − | − | − | − | + | G3 | 5.83 |
KP-007a | S | 661 | − | − | 1.04 ± 0.08 | <0.5 | x | − | − | − | − | − | − | G2 | >6.84 |
KP-232c | E1 | 65 | − | − | 3.95 ± 0.46 | >2 | 2 | + | + | − | − | − | + | G5 | 5.05 |
KP-960b | N2 | 15 | − | − | 1.27 ± 0.17 | <0.5 | 5 | − | − | − | + | − | − | G6 | >6.71 |
Primary meningitis (n = 20) | |||||||||||||||
KP-002a | C4 | 23 | − | − | 2.42 ± 0.33 | >2 | 1 | + | − | − | + | + | + | G5 | 4.83 |
KP-003a | C5 | 23 | − | − | 10.73 ± 1.11 | >2 | 1 | + | + | − | + | + | + | G6 | 4.50 |
KP-005a | M | 268 | − | − | 7.24 ± 0.76 | >2 | 20 | + | + | − | − | − | + | G5 | >6.49 |
KP-006a | Q | 65 | − | − | 3.67 ± 0.42 | 0.5–1 | 2 | + | + | − | − | − | + | G6 | 4.41 |
KP-064c | R1 | 218 | − | − | 3.74 ± 0.49 | >2 | 57 | + | + | − | − | − | + | G2 | >6.45 |
KP-088c | P2 | 373 | − | − | 4.77 ± 0.46 | >2 | 2 | + | + | − | − | − | + | G6 | 1.59 |
KP-477c | C3 | 23 | − | − | 7.75 ± 1.37 | >2 | 1 | + | + | + | + | + | + | G5 | 4.41 |
KP-600c | C1 | 23 | − | − | 2.33 ± 0.24 | <0.5 | x | − | − | − | − | − | − | G2 | >6.45 |
KP-777c | C2 | 23* | − | − | 5.30 ± 0.71 | >2 | 1 | + | + | + | + | + | + | G6 | 4.98 |
KP-164c | R1 | 218 | − | − | 3.04 ± 0.48 | >2 | 57 | + | + | − | − | − | − | G3 | >6.15 |
KP-552b | B | 23 | − | − | 7.05 ± 0.72 | >2 | 1 | + | + | − | + | + | + | G5 | 5.35 |
KP-780b | P1 | 373 | − | − | 6.92 ± 0.53 | >2 | 2 | + | + | − | − | − | + | G6 | >6.44 |
KP-783b | P1 | 373 | − | − | 3.06 ± 0.43 | >2 | 2 | + | + | − | − | − | + | G6 | 5.4 |
KP-957b | K | 65 | − | − | 4.56 ± 0.56 | >2 | 2 | + | + | − | − | − | + | G6 | 3.94 |
KP-958b | I2 | 86* | − | − | 3.45 ± 0.49 | >2 | 2 | + | + | − | − | − | + | G5 | 1.56 |
KP-959b | unidentified | 1049 | − | − | 4.71 ± 0.89 | >2 | 5 | + | + | − | + | - | + | G6 | >6.50 |
KP-961b | J2 | 373 | − | − | 4.58 ± 0.39 | >2 | 2 | + | + | − | − | − | + | G6 | 3.77 |
KP-962b | F | 1544 | − | − | 5.09 ± 1.06 | 0.5–1 | 20 | + | + | − | + | − | + | G6 | 5.14 |
KP-963b | H2 | 29 | − | − | 4.51 ± 0.53 | >2 | 54 | + | + | − | − | − | + | G6 | 5.41 |
KP-966b | L | 592 | − | − | 2.75 ± 0.45 | 0.5–1 | 57 | + | − | − | − | − | + | G2 | >6.59 |
