Figure 8
From: In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing
Impact of SOCS-4 suppression on HaCaT phosphorylation status. Summary of Kinexus protein microarray analysis highlighting the ten most highly upregulated (a) and down regulated (b) phospho proteins within HaCaT keratinocytes following SOCS-4 knockdown.[Met, met proto-oncogene; PDGFRa, platelet derived growth factor receptor alpha; shc1, SH2 domain-containing transforming protein 1; PKR1, Double-stranded RNA-dependent protein-serine kinase; CDK1/2, cyclin-dependent kinase 1/2; IkBe, NFKB inhibitor epsilon; HDAC5, Histone deacetylase 5; FKHR. Forkhead box protein O1; JNK1/2/3, c- Jun N-terminal kinase 1/2/3; CDK4, Cyclin-dependent protein-serine kinase 4; RSK1/2/3, Ribosomal S6 protein-serine kinase 1/2/3; S6K, Ribosomal protein S6 kinase beta-1; VEGFR2, Vascular endothelial growth factor receptor-tyrosine kinase 2; c-Cbl, Signal transduction protein CBL; Src, Src proto-oncogene-encoded protein-tyrosine kinase; EGFR, Epidermal growth factor receptor-tyrosine kinase; FAK, Focal adhesion kinase; IRS1, Insulin receptor substrate 1; Rb, Retinoblastoma-associated protein 1].
