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Figure 1

From: Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis

Figure 1

Tumor-bearing mice display systemic signs of neutrophil activation. 4T1 tumor cells (5 × 104) were orthotopically injected into the mammary fat pads of female BALB/c mice. Blood was collected for hemogram analysis 21 days after tumor cell inoculation as described in the Methods section. The following parameters were analyzed: (A) hematocrit; (B) platelet count; (C) monocyte count; (D) lymphocyte count and (E) neutrophil count in control (open bars) and 4T1 tumor-bearing mice (black bars). The plasma levels of (F) DNA and (G) myeloperoxidase (MPO) were evaluated in control (open bars) and 4T1-bearing mice (black bars) as described in the Methods section. *P < 0.05; **P < 0.01; unpaired, two-tailed Student’s t-test. N = 5 mice per group.

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