Figure 8
From: TDP-43 stabilises the processing intermediates of mitochondrial transcripts
Hypothetical scheme for the effect of increased TDP-43 level on mt polycistronic transcripts. Overexpression of TDP-43 causes an increase in TDP-43 level in mitochondria. The excess TDP-43 stabilises the L-strand transcript (dashed red line) by binding directly to regions corresponding to mt-tRNAPro (Pro), mt-tRNAAsn (Asn), and mt-tRNAGln (Gln), and the resulting L-strand-derived transcript (solid red line), and then stabilises one of the transcripts from the H-strand (solid blue line) via complementary double-stand formation. The increased TDP-43 level in mitochondria thereby causes unbalanced processing the mt-transcript, resulting in deregulation of mitochondrial protein synthesis.
