Figure 5

Osteopenia associated with high bone turnover is reduced in mice lacking NLRP3. (a) VivaCT analysis was performed on the femurs of 4-month old WT and Nlrp3 ^−/− female mice before and at 8 weeks after OVX or sham surgery. (b) VivaCT analysis of 4-month old WT and Nlrp3 ^−/− male mice exposed to PTH (80 μg/kg/day) or vehicle for 2 weeks via osmotic pumps. Data are means ± SD of the percentage of changes relative to baseline (before surgery or treatment) of 4–6 mice/group; (a) *p = 0.0111; (b) **p = 0.0017. (c) Post-mortem µCT scan was performed on the femurs from 3-month old WT and Nlrp3 ^−/− male mice exposed to acute RANKL treatment (1 µg/kg once a day, for 2 days). Data are means ± SD of 4–7 mice/group; **p = 0.0062.