Figure 2
From: Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia
Transthyretin is carried by placental extracellular vesicles. Representative Western blots showing the presence of transthyretin in different fractions of extracellular vesicles extruded from first trimester and term placental explants (A,C). Full-length blots are presented in Supplementary Figure 2. Semi-quantitative analyses of the levels of transthyretin relative to the levels of β-actin show that there were significantly higher levels of transthyretin in micro- (*p = 0.011, n = 5) and nano- (**p = 0.0099, n = 5) vesicles compared with macro-vesicles from first trimester placentae (B). Transthyretin was not carried by macro-vesicles from term placentae (D). Data is plotted as box-whisker plots showing the median, interquartile range (box) and maximum/minimum (whiskers).
