Table 2 Genes showing significantly different expression in whole interstitial, small interstitial and large alveolar macrophages from COPD patients.

From: Characterisation of lung macrophage subpopulations in COPD patients and controls

Gene name	Gene ID	P Value	Fold change	Function
Interstitial macrophages v Alveolar macrophages
NLRP3	Hs00918082_m1	0.0009	20.08	Inflammation /// immune response /// apoptosis
IL1B	Hs01555410_m1	0.0039	16.19	Cytokine /// inflammation /// cell proliferation and differentiation /// apoptosis
IL1RL1	Hs00545033_m1	0.0004	15.76	Cytokine receptor /// pro-inflammatory
IL6	Hs00985639_m1	0.0016	15.48	Cytokine /// pro and anti-inflammatory
SFTPD	Hs00358340_m1	0.0002	13.62	Surfactant protein /// host defence
IL10	Hs00961622_m1	0.0002	13.59	Cytokine /// immunoregulatory
MUC5B	Hs00861595_m1	0.0002	12.97	Mucin /// host defence
SFTPA1	Hs00831305_s1	0.0005	12.8	Surfactant protein /// host defence
CXCL1	Hs00605382_g1	0.0001	12.19	Growth factor /// neutrophil chemoattractant
MUC1	Hs00159357_m1	0.0001	12.11	Mucin /// host defence
Small Interstitial macrophages v Small Alveolar macrophages
CCL20	Hs01011368_m1	0.0050	114.21	Lymphocyte chemoattractant
CXCL1	Hs00605382_gH	0.0018	16.56	Growth factor /// neutrophil chemoattractant
LTF	Hs00914334_m1	0.0026	11.91	Transferrin /// iron homeostasis /// host defence /// anti-inflammatory
INHBB	Hs00173582_m1	0.0006	11.06	Inhibin /// negative regulator of cell proliferation /// tumour-suppressor
CCL3	Hs00234142_m1	0.0073	10.63	Acute inflammation /// granulocyte recruitment
MUC5B	Hs00861595_m1	0.0011	10.09	Mucin /// host defence
ICAM1	Hs00164932_m1	0.0063	9.77	Adhesion /// transmigration
VEGFA	Hs00900055_m1	0.0066	6.26	Growth factor /// angiogenesis /// cell migration /// apoptosis inhibition
IL1R1	Hs00991002_m1	0.0061	5.44	Cytokine receptor /// pro-inflammatory
TLR3	Hs01551078_m1	0.0093	5.36	Host defense against viruses
Large Alveolar macrophages v Small Alveolar macrophages
INHBA	Hs01081598_m1	0.0005	31.31	Inhibin and activin /// negative regulation of cell proliferation
CXCL5	Hs00171085_m1	0.0030	24.42	Neutrophil chemotaxis
VEGFA	Hs00900055_m1	0.0006	−6.67	Growth factor /// angiogenesis /// cell migration /// apoptosis inhibition
SFTPD	Hs00358340_m1	0.0042	−7.14	Surfactant protein /// host defence
CCL17	Hs00171074_m1	0.0007	−7.14	T cell chemotaxis
TLR2	Hs01872448_s1	<0.0001	−7.69	Host response to Gram-positive bacteria and yeast
NLRP3	Hs00918082_m1	0.0004	−9.09	Inflammation /// immune response /// apoptosis
IL1R2	Hs01030384_m1	0.0007	−10.00	Decoy receptor /// inhibitory signal /// anti-inflammatory
SFTPA1	Hs00831305_s1	0.0006	−14.29	Surfactant protein /// host defence
CCL22	Hs01574247_m1	<0.0001	−16.67	Chemokine /// trafficking of activated T lymphocytes to inflammatory sites

The 10 most highly up and down regulated genes are shown. The full lists of genes are shown in Tables S9, S11 and S12. Macrophage mRNA was analysed using a Custom Made Taqman Assay and data was analysed with whole alveolar macrophages or small alveolar macrophages as the reference. Paired t test (two tailed) was performed and p < 0.01 for all genes.

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Table 2 Genes showing significantly different expression in whole interstitial, small interstitial and large alveolar macrophages from COPD patients.

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