Figure 7

Network analysis for the differentially expressed genes (DEGs) in the intestine following exposure to FX or DON. To create gene networks, DEGs following exposure to FX 2 µM (a), FX 10 µM (b) or DON 10 µM (c) were overlaid onto a global molecular network that was developed from information contained in the Ingenuity Knowledge Base. The IPA Network Generation Algorithm links genes based on experimentally observed interactions and orders these genes based on their interconnectedness. Generally, the more interactions with other network members, the more central a gene will be in a network. In the networks, the edges or arrows indicate gene interactions. Only direct interactions have been considered. Red nodes represent up-regulated genes, and green nodes represent down-regulated genes identified in our differential expression analysis. Darker node colors indicate more extreme (high or low) up- or down-regulation of the respective gene. White nodes represent genes that were not originally identified in our microarray analysis but were are predicted by IPA to be involved in the network.