Figure 5

Phylogenetic tree with driver mutation status and CLEAR score. The region tree provides the information of the connection of sample diversity, prognosis and the driver gene mutation. The region tree shows majority of sample regions are clustered together with their siblings with several exceptions caused by intra-tumor heterogeneity and PBRM1 is associated with regions with low prognosis score, while SETD2, BAP1 and KDM5C are associated with the poor prognosis sample regions.