Table 3 Subgroup analysis of NOD risk associated with TG according to covariates by logistic regression.

From: Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial

Subgroups

Continuous

 

Categorical

P for interaction between the two factors

Events, n (%)/n

OR (95%CI)

P value

P for interaction between the two factors

Normal

Abnormal

OR (95%CI)

P value

Events, n (%)/N

Events, n (%)/N

Age

   

0.792

    

0.533

    <60

777 (10.4)/7648

1.18 (1.11, 1.26)

<0.001

 

419 (8.9)/4718

358 (13.0)/2750

1.30 (1.10, 1.52)

0.002

 

    ≥60

838 (11.3)/7396

1.20 (1.10, 1.30)

<0.001

 

482 (9.6)/5025

356 (15.0)/2731

1.41 (1.20, 1.65)

<0.001

 

Center*

   

0.026

    

0.028

    Anqing

418 (11.1)/3765

1.27 (1.13, 1.43)

<0.001

 

253 (9.2)/2763

165 (16.5)/1002

1.57 (1.24, 2.00)

<0.001

 

    Lianyungang

1197 (10.8)/11,099

1.16 (1.10, 1.23)

<0.001

 

648 (9.3)/6980

549 (13.3)/4119

1.28 (1.12, 1.45)

<0.001

 

Gender

   

0.415

    

0.896

    Males

657 (10.8)/6056

1.17 (1.09, 1.25)

<0.001

 

417 (9.4)/4432

240 (14.8)/1624

1.38 (1.14, 1.66)

<0.001

 

    Females

958 (10.9)/8808

1.21 (1.12, 1.30)

<0.001

 

484 (9.1)/5311

474 (13.6)/3497

1.33(1.15, 1.54)

<0.001

 

Treatment group

   

0.767

    

0.974

    Enalapril

795 (10.7)/7444

1.18 (1.09, 1.27)

<0.001

 

442 (9.1)/4855

353 (13.6)/2589

1.30 (1.10, 1.52)

0.002

 

    Enalapril-folic acid

820 (11.1)/7420

1.20 (1.12, 1.29)

<0.001

 

459 (9.4)/4888

361 (14.3)/2532

1.41 (1.20, 1.66)

<0.001

 

Smoking status

   

0.352

    

0.223

    Never

1096 (10.7)/10,263

1.16 (1.09, 1.24)

<0.001

 

587 (9.2)/6400

509 (13.2)/3863

1.27 (1.11, 1.46)

<0.001

 

    Ever

132 (12.2)/1084

1.14 (0.92, 1.41)

0.234

 

78 (10.2)/762

54 (16.8)/322

1.46 (0.97, 2.22)

0.073

 

    Current

386 (11.0)/3510

1.23 (1.12, 1.35)

<0.001

 

235 (9.1)/2577

151 (16.2)/933

1.53 (1.20, 1.96)

<0.001

 

Alcohol

   

0.430

    

0.957

    Never

1112 (10.8)/10,277

1.21 (1.13, 1.29)

<0.001

 

582 (9.0)/6435

530 (13.8)/3842

1.35 (1.18, 1.54)

<0.001

 

    Ever

131 (12.8)/1022

1.32 (1.05, 1.65)

0.016

 

82 (11.5)/634

49 (16.0)/306

1.35 (0.881, 2.07)

0.168

 

    Current

371 (10.4)/3554

1.14 (1.05, 1.24)

0.002

 

236 (9.1)/2584

135 (13.9)/970

1.34 (1.04, 1.72)

0.022

 

BMI

   

0.486

     

    <24

523 (8.3)/6283

1.12 (1.02, 1.22)

0.015

 

393 (7.9)/4947

130 (9.7)/1336

1.16 (0.95, 1.43)

0.139

0.345

    ≥24, <28

643 (11.1)/5786

1.14 (1.07, 1.21)

<0.001

 

339 (9.8)/3468

304 (13.1)/2318

1.28 (1.09, 1.49)

0.002

 

    ≥28

448 (16.1)/2790

1.04 (1.02, 1.05)

<0.001

 

168 (12.7)/1323

280 (19.1)/1467

1.36 (1.12, 1.65)

0.002

 

SBP, mmHg

   

0.304

    

0.930

    <140

90 (10.6)/853

1.36 (1.08, 1.72)

0.009

 

48 (8.5)/562

42 (14.4)/291

1.43 (0.87, 2.34)

0.160

 

    ≥140, <160

495 (10.4)/4759

1.19 (1.08, 1.31)

<0.001

 

276 (8.7)/3180

219 (13.9)/1579

1.34 (1.09, 1.65)

0.005

 

    ≥160, <180

595 (10.5)/5691

1.12 (1.03, 1.22)

0.011

 

334 (8.9)/3739

261 (13.4)/1952

1.31 (1.09, 1.58)

0.004

 

    ≥180

435 (12.2)/3561

1.21 (1.11, 1.33)

<0.001

 

243 (10.7)/2262

192 (14.8)/1299

1.36 (1.09, 1.69)

0.006

 

DBP, mmHg

   

0.884

    

0.344

    <90

531 (10.9/4882)

1.19 (1.07, 1.32)

0.001

 

309 (9.2)/3360

222 (14.6)/1522

1.40 (1.15, 1.72)

<0.001

 

    ≥90, <100

551 (10.8)/5125

1.17 (1.07, 1.28)

<0.001

 

308 (9.2)/3336

243 (13.6)/1789

1.33 (1.09, 1.61)

0.004

 

    ≥100, <110

368 (10.9)/3390

1.16 (1.04, 1.29)

0.007

 

204 (9.5)/2142

164 (13.1)/1248

1.19 (0.94, 1.50)

0.148

 

    ≥110

165 (11.2)/1467

1.26 (1.13, 1.42)

<0.001

 

80 (8.8)/905

85 (15.1)/562

1.68 (1.18, 2.39)

0.004

 

Folic acid, ng/ml

   

0.672

    

0.104

    <8.1

860 (11.5)/7510

1.17 (1.09, 1.25)

<0.001

 

461 (10.0)/4623

399 (13.8)/2887

1.21 (1.04, 1.41)

0.016

 

    ≥8.1

746 (10.3)/7233

1.20 (1.11, 1.30)

<0.001

 

434 (8.6)/5044

312 (14.3)/2189

1.50 (1.27, 1.78)

<0.001

 

Hcy, μmol/l

   

0.565

    

0.418

    <10

305 (10.4)/2944

1.14 (1.02, 1.27)

0.018

 

160 (8.4)/1896

145 (13.8)/1048

1.42 (1.10, 1.84)

0.008

 

    ≥10

1310 (11.0)/11,914

1.20 (1.13, 1.27)

<0.001

 

741 (9.4)/7844

569 (14.0)/4070

1.33 (1.17, 1.50)

<0.001

 

MTHFR C677T,

   

0.064

    

0.044

    CC

436 (10.7)/4092

1.13 (1.03, 1.24)

0.008

 

251 (9.2)/2762

185 (13.5)/1366

1.28 (1.03, 1.60)

0.029

 

    CT

767 (10.5)/7312

1.27 (1.17, 1.37)

<0.001

 

408 (8.5)/4796

359 (14.3)/2516

1.54 (1.30, 1.81)

<0.001

 

    TT

412 (11.9)/3460

1.11 (1.00, 1.23)

0.050

 

242 (10.9)/2221

170 (13.7)/1239

1.11 (0.885, 1.39)

0.369

 
  1. Abbreviations: SBP = systolic blood pressure, DBP = diastolic blood pressure, TG = triglycerides, HDL = high-density lipoprotein, TC = total cholesterol, HCY = homocysteine, NOD = new-onset diabetes. MTHFR = methylenetetrahydrofolate reductase.
  2. Adjusted for age, gender, clinical center, SBP, DBP, smoking and drinking status, baseline FPG, and BMI, if not stratified. Only TG levels were analyzed because of colinearity with TC and HDL.
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