Table 4 Subgroup analysis of NOD risk associated with TC according to important covariates by logistic regression.

Age

0.517

0.47

    <60

777 (10.4)/7648

0.97 (0.90, 1.04)

0.394

322 (10.4)/3087

455 (10.4)/4381

0.85 (0.72, 1.00)

0.044

    ≥60

838 (11.3)/7396

0.93 (0.86, 0.99)

0.033

358 (11.0)/3255

480 (11.6)/4141

0.90 (0.76, 1.05)

0.173

Center*

0.938

0.458

    Anqing

418 (11.1)/3765

0.93 (0.83, 1.04)

0.195

259 (10.8)/2393

159 (11.6)/1372

0.90 (0.72, 1.12)

0.345

    Lianyungang

1197 (10.8)/11,099

0.95 (0.90, 1.00)

0.066

421 (10.7)/3949

776 (10.9)/7150

0.85(0.74, 0.97)

0.015

Gender

0.079

0.199

    Males

657 (10.8)/6056

1.00 (0.93, 1.09)

0.918

308 (10.4)/2953

349 (11.2)/3103

0.94(0.79, 1.12)

0.508

    Females

958 (10.9)/8808

0.91 (0.86, 0.97)

0.005

372 (11.0)/3389

586 (10.8)/5419

0.82 (0.70, 0.95)

0.008

Treatment-group

0.034

0.253

    Enalapril

795 (10.7)/7444

0.98 (0.92, 1.05)

0.633

329 (10.3)/3196

466 (11.0)/4248

0.90(0.76, 1.05)

0.184

    Enalapril-folic acid

820 (11.1)/7420

0.91 (0.85, 0.98)

0.011

351 (11.2)3146

469 (11.0)/4274

0.85 (0.72, 0.99)

0.039

Smoking status

0.036

0.054

    Never

1096 (10.7)/10,263

0.92 (0.87, 0.98)

0.008

458 (10.9)/4210

638 (10.5)/6053

0.82(0.72, 0.94)

0.006

    Ever

132 (12.2)/1084

0.90 (0.75, 1.08)

0.259

64 (12.4)/517

68 (12.0)/567

0.77 (0.51, 1.14)

0.193

    Current

386 (11.0)/3510

0.99 (0.89, 1.10)

0.877

157 (9.7)/1612

229 (12.1)/1898

1.05 (0.82, 1.33)

0.714

Alcohol

0.088

0.169

    Never

1112 (10.8)/10,277

0.95 (0.89, 1.01)

0.073

463 (10.7)/4329

649 (10.9)/5948

0.86 (0.75, 0.99)

0.032

    Ever

131 (12.8)/1022

0.81 (0.67, 0.99)

0.034

76 (13.8)/550

55 (11.7)/472

0.68 (0.45, 1.02)

0.064

    Current

371 (10.4)/3554

0.98 (0.89, 1.09)

0.769

140 (9.6)/1459

231 (11.0)/2095

0.97 (0.76, 1.23)

0.794

BMI

0.436

0.523

    <24

523 (8.3)/6283

0.85 (0.78, 0.93)

<0.001

260 (8.4)/3093

263 (8.2)/3190

0.71 (0.59, 0.86)

<0.001

    ≥24, <28

643 (11.1)/5786

0.79 (0.73, 0.85)

<0.001

262 (11.7)/2245

381 (10.8)/3541

0.64 (0.54, 0.76)

<0.001

    ≥28

448 (16.1)/2790

0.85(0.78, 0.92)

<0.001

158 (15.7)/1004

290 (16.2)/1786

0.69 (0.56, 0.84)

<0.001

SBP, mmHg

0.990

0.789

    <140

90 (10.6)/853

1.00 (0.80, 1.25)

0.971

46 (10.7)/428

44 (10.4)/425

0.86 (0.53, 1.40)

0.547

    ≥140, <160

495 (10.4)/4759

0.95 (0.87, 1.04)

0.274

232 (10.5)/2218

263 (10.4)/2541

0.82 (0.67, 1.00)

0.055

    ≥160, <180

595 (10.5)/5691

0.94 (0.87, 1.03)

0.170

251 (10.6)/2379

344 (10.4)/3312

0.85 (0.70, 1.03)

0.091

    ≥180

435 (12.2)/3561

0.94 (0.86, 1.04)

0.225

151 (11.5)/1317

284 (12.7)/2244

0.96 (0.77, 1.20)

0.731

DBP, mmHg

0.756

0.910

    <90

531 (10.9/4882)

0.95 (0.87, 1.04)

0.283

254 (10.9)/2340

277 (10.9)/2542

0.84 (0.69, 1.02)

0.085

    ≥90, <100

551 (10.8)/5125

0.93 (0.85, 1.01)

0.075

231 (10.8)/2145

320 (10.7)/2980

0.87(0.72, 1.06)

0.166

    ≥100, <110

368 (10.9)/3390

0.93 (0.84, 1.04)

0.201

142 (10.7)/1328

226 (11.0)/2062

0.84 (0.66, 1.07)

0.162

    ≥110

165 (11.2)/1467

1.01 (0.87, 1.18)

0.854

53 (10.0)/529

112 (11.9)/938

1.01 (0.70, 1.47)

0.956

Folic acid, ng/ml

0.647

0.355

    <8.1

860 (11.5)/7510

0.96 (0.89, 1.02)

0.201

339 (11.1)/3064

521 (11.7)/4446

0.91 (0.78, 1.07)

0.257

    >8.1

746 (10.3)/7233

0.94 (0.87, 1.01)

0.097

336 (10.4)/3216

410 (10.2)/4017

0.83 (0.70, 0.98)

0.031

Hcy, μmol/l

0.66

0.967

    <10

305 (10.4)/2944

0.96 (0.86, 1.07)

0.474

131 (10.0)/1312

174 (10.7)/1632

0.86 (0.67, 1.12)

0.271

    >10

1310 (11.0)/11,914

0.94 (0.89, 1.00)

0.033

549 (10.9)/5028

761 (11.1)/6886

0.87 (0.76, 0.99)

0.029

MTHFR C677T

0.927

0.507

    CC

436 (10.7)/4092

0.95 (0.86, 1.05)

0.295

202 (10.7)/1885

234 (10.6)/2207

0.84 (0.67, 1.05)

0.119

    CT

767 (10.5)/7312

0.94 (0.87, 1.01)

0.085

330 (10.7)/3098

437 (10.4)/4214

0.84 (0.71, 0.98)

0.032

    TT

412 (11.9)/3460

0.96 (0.87, 1.06)

0.440

148 (10.9)/1359

264 (12.6)/2101

0.97 (0.77, 1.22)

0.777