Table 5 Subgroup analysis of NOD risk associated with HDL according to important covariates by logistic regression.

Age

0.293

0.321

    <60

777 (10.4)/7648

0.87 (0.69, 1.11)

0.262

340 (11.9)/2862

437 (9.5)/4606

0.86 (0.72, 1.02)

0.083

    ≥60

838 (11.3)/7396

0.71 (0.56, 0.89)

0.004

338 (13.9)/2440

500 (10.1)/4956

0.77 (0.65, 0.92)

0.003

Center*

<0.001

0.028

    Anqing

418 (11.1)/3765

0.42 (0.29, 0.61)

<0.001

179 (15.3)/1173

239 (9.2)/2592

0.61 (0.47, 0.79)

<0.001

    Lianyungang

1197 (10.8)/11,099

0.94 (0.78, 1.13)

0.492

499 (12.1)/4129

698 (10.0)/6970

0.89 (0.77, 1.02)

0.098

Gender

0.199

0.262

    Males

657 (10.8)/6056

0.88 (0.67, 1.13)

0.311

115 (12.9)/892

542 (10.5)/5164

0.92 (0.73, 1.16)

0.498

    Females

958 (10.9)/8808

0.73 (0.58, 0.91)

0.006

563 (12.8)/4410

395 (9.0)/4398

0.79 (0.68, 0.91)

0.001

Treatment group

0.922

0.194

    Enalapril

795 (10.7)/7444

0.79 (0.63, 1.01)

0.057

348 (13.1)/2665

447 (9.4)/4779

0.78 (0.65, 0.92)

0.004

    Enalapril-folic acid

820 (11.1)/7420

0.77 (0.61, 0.97)

0.027

330 (12.5)/2637

490 (10.2)/4783

0.85 (0.72, 1.01)

0.063

Smoking status

0.598

0.458

    Never

1096 (10.7)/10263

0.76(0.62, 0.94)

0.010

569 (12.5)/4548

527 (9.2)/5715

0.80 (0.70, 0.92)

0.002

    Ever

132 (12.2)/1084

0.62 (0.35, 1.12)

0.111

37 (16.9)/219

95 (11.0)/865

0.63 (0.39, 1.00)

0.048

    Current

386 (11.0)/3510

0.94 (0.68, 1.28)

0.682

71 (13.3)/532

315 (10.6)/2978

1.01 (0.74, 1.38)

0.954

Alcohol

0.356

0.030

    Never

1112 (10.8)/10,277

0.77 (0.63, 0.95)

0.016

582 (12.7)/4589

530 (9.3)/5688

0.83 (0.73, 0.95)

0.008

    Ever

131 (12.8)/1022

0.52 (0.27, 0.99)

0.048

52 (18.3)/284

79 (10.7)/738

0.47 (0.31, 0.72)

<0.001

    Current

371 (10.4)/3554

0.90 (0.66, 1.21)

0.477

43 (10.1)/424

328 (10.5)/3130

1.08 (0.75, 1.55)

0.686

BMI

0.242

0.652

    <24

523 (8.3)/6283

0.72 (0.56, 0.92)

0.008

129 (8.7)/1491

394 (8.2)/4792

0.74(0.59, 0.92)

0.007

    ≥24, <28

643 (11.1)/5786

0.57 (0.45, 0.74)

<0.001

293 (12.4)/2368

350 (10.2)/3418

0.67 (0.56, 0.79)

<0.001

    ≥28

448 (16.1)/2790

0.49 (0.35, 0.69)

<0.001

256 (17.7)/1443

192 (14.3)/1347

0.65 (0.53, 0.80)

<0.001

SBP, mmHg

0.524

0.800

    <140

90 (10.6)/853

0.96(0.45, 2.05)

0.913

41 (13.0)/316

49 (9.1)/537

0.73 (0.43, 1.23)

0.239

    ≥140, <160

495 (10.4)/4759

0.72 (0.53, 0.98)

0.035

214 (12.4)/1719

281 (9.2)/3040

0.83 (0.66, 1.03)

0.089

    ≥160, <180

595 (10.5)/5691

0.80 (0.61, 1.05)

0.103

248 (12.4)/2004

347 (9.4)/3687

0.82 (0.67, 1.00)

0.049

    ≥180

435 (12.2)/3561

0.83 (0.61, 1.12)

0.223

175 (13.9)/1263

260 (11.3)/2298

0.82 (0.65, 1.04)

0.100

DBP, mmHg

0.182

0.430

    <90

531 (10.9/4882)

0.67 (0.50, 0.90)

0.008

240 (13.3)/1811

291 (9.5)/3071

0.76 (0.62, 0.94)

0.010

    ≥90, <100

551 (10.8)/5125

0.84(0.63, 1.11)

0.224

228 (12.3)/1847

323 (9.9)/3278

0.81 (0.66, 0.99)

0.044

    ≥100, <110

368 (10.9)/3390

0.97 (0.70, 1.35)

0.863

143 (12.3)/1166

225 (10.1)/2224

0.95 (0.74, 1.24)

0.721

    ≥110

165 (11.2)/1467

0.57 (0.33, 0.99)

0.047

67 (14.0)/478

98 (9.9)/989

0.75 (0.51, 1.11)

0.146

Folic acid, ng/ml

0.027

0.498

    <8.1

860 (11.5)/7510

0.95 (0.76, 1.19)

0.678

370 (13.3)/2784

490 (10.4)/4726

0.88 (0.74, 1.04)

0.135

    ≥8.1

746 (10.3)/7233

0.65 (0.51, 0.83)

<0.001

305 (12.3)/2472

441 (9.3)/4761

0.76 (0.64, 0.91)

0.003

Hcy, μmol/l

0.457

0.504

    <10

305 (10.4)/2944

0.73 (0.50, 1.07)

0.110

156 (12.4)/1262

149 (8.9)/1682

0.76 (0.58, 0.99)

0.043

    ≥10

1310 (11.0)/11,914

0.80 (0.66, 0.96)

0.016

522 (12.9)/4036

788 (10.0)/7878

0.83 (0.72, 0.95)

0.007

MTHFR C677T

0.055

0.193

    CC

436 (10.7)/4092

0.62(0.45, 0.86)

0.004

179 (12.6)/1417

257 (9.6)/2675

0.82 (0.64, 1.03)

0.092

    CT

767 (10.5)/7312

0.78 (0.61, 0.99)

0.043

338 (12.8)/2644

429 (9.2)/4668

0.76 (0.64, 0.91)

0.002

    TT

412 (11.9)/3460

1.01 (0.74, 1.39)

0.936

161 (13.0)/1241

251 (11.3)/2219

0.93 (0.73, 1.19)

0.572