Figure 3
From: The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
Effect of XCR1 targeting and MPL adjuvant on the anti-M2e IgG response in seronegative pigs. Pigs were inoculated twice (D0 and D28) intradermally with 0.25 or 2.5 µg of poXCL1-M2e or NIP-M2e VB with or without CL + MPL. In (A and B), the anti-M2e IgG titers obtained in the different groups at D28 (A) and at D56 (B) are shown. Signals with sera from D0 were all at the level of background. In (C), as neither the dose nor the formulated MPL were confounding factors, the NIP-M2e and the poXCL1-M2e vaccinated groups were combined to increase the statistical power. In (D and E), the IgG1 and IgG2 anti-M2e titers at D56 are shown for the different groups. In all panels, each dot corresponds to individual pig values. Arithmetic means and standard errors of the mean are shown. Statistical significance between 2 groups was calculated with unpaired t-test (p values are reported when > 0.05, * < 0.05; ** < 0.01).
