Figure 6
Non-genetic, in-utero factors that may contribute to development of neurodevelopmental disorders. A mother persistently encounters challenging environmental conditions, maternal factors impact how she relates with these conditions and impact how the stress is translated to her developing offspring. Genetically equivalent embryos face varying environmental conditions depending on the maternal environment and maternal response to her environment. Variables reported in this study using a mouse model are indicated by boxes with solid line, variables prevalent in the literature and could be tested in a mouse model and/or in humans are indicated by boxes with dotted line, and a variable that is not relevant for a mouse in laboratory conditions but salient for ASD-risk in humans is shown by an asterisk.
