Table 1 Concentrations of MNZ, MNZ-OH and MAA in tissues of pigs after oral administration of metronidazole for 7 consecutive days (μg kg−1) (n = 4, Mean ± SD).
From: Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
Tissues | compounds | concentration (μg kg−1) | |||||
|---|---|---|---|---|---|---|---|
6h | 1d | 3d | 5d | 7d | 14d | ||
Liver | MNZ | 3576 ± 682 | 656 ± 105 | 196 ± 28 | 73 ± 15 | 34 ± 10 | 5 ± 2 |
MNZ-OH | 622 ± 88 | 152 ± 38 | 54 ± 15 | 21 ± 6 | 9 ± 2 | ND | |
MAA | 58 ± 12 | 16 ± 4 | ND | ND | ND | ND | |
Kidney | MNZ | 4256 ± 712 | 731 ± 156 | 205 ± 54 | 891 ± 26 | 41 ± 10 | 8 ± 2 |
MNZ-OH | 569 ± 63 | 149 ± 24 | 46 ± 9 | 20 ± 5 | 11 ± 2 | ND | |
MAA | 46 ± 9 | 26 ± 5 | ND | ND | ND | ND | |
Muscle | MNZ | 2289 ± 353 | 350 ± 81 | 105 ± 16 | 32 ± 10 | 18 ± 6 | 2 ± 1 |
MNZ-OH | 325 ± 62 | 96 ± 20 | 32 ± 7 | 15 ± 4 | 4 ± 1 | ND | |
MAA | 23 ± 7 | 8 ± 5 | ND | ND | ND | ND | |
Fat | MNZ | 854 ± 149 | 126 ± 41 | 27 ± 6 | 11 ± 4 | 2 ± 1 | ND |
MNZ-OH | 203 ± 24 | 57 ± 12 | 12 ± 4 | ND | ND | ND | |
MAA | ND | ND | ND | ND | ND | ND | |
Heart | MNZ | 2151 ± 386 | 251 ± 31 | 32 ± 10 | 15 ± 4 | 6 ± 3 | ND |
MNZ-OH | 189 ± 27 | 24 ± 2 | ND | ND | ND | ND | |
MAA | 36 ± 7 | 6 ± 2 | ND | ND | ND | ND | |
Lung | MNZ | 3075 ± 489 | 151 ± 42 | 21 ± 6 | 10 ± 2 | 4 ± 2 | ND |
MNZ-OH | 492 ± 26 | 96 ± 25 | 14 ± 4 | ND | ND | ND | |
MAA | 47 ± 5 | 8 ± 3 | ND | ND | ND | ND | |
Stomach | MNZ | 2885 ± 401 | 139 ± 41 | 35 ± 10 | 11 ± 5 | 3 ± 1 | ND |
MNZ-OH | 241 ± 61 | 55 ± 13 | 7 ± 2 | ND | ND | ND | |
MAA | 26 ± 4 | ND | ND | ND | ND | ND | |
Large intestine | MNZ | 2611 ± 241 | 112 ± 29 | 57 ± 13 | 16 ± 5 | 3 ± 2 | ND |
MNZ-OH | 370 ± 41 | 64 ± 15 | 22 ± 6 | 6 ± 2 | ND | ND | |
MAA | 36 ± 5 | ND | ND | ND | ND | ND | |
Small intestine | MNZ | 2972 ± 409 | 235 ± 23 | 65 ± 14 | 18 ± 5 | 4 ± 2 | ND |
MNZ-OH | 330 ± 34 | 57 ± 14 | 16 ± 2 | 4 ± 2 | ND | ND | |
MAA | 23 ± 4 | ND | ND | ND | ND | ND | |
