Table 2 Histopathological scoring system used to assess inflammatory change in lung.

From: Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Histopathology grade

Perivascular and peribronchiola eosinophilia

Oedema

Epithelial damage

0

Normal

Normal

Normal

1

Lowgrade cell influx, no tissue pathology

Low grade diffuse oedema

Low grade cell loss

2

Low to moderate cell influx, low grade tissue damage

Moderate alveolar and bronchiolar oedema

Low grade cell loss

3

Moderate cell influx, low grade tissue damage

Regional and focal oedema

Moderate cell loss

4

Moderate to high cell influx, marked tissue damage

Pronounced oedema

Moderate cell loss

5

High cell influx, significant tissue pathology

Pneumonic type oedema

Epithelial metaplasia, mucus cell hyperplasia