Figure 3 | Scientific Reports

Figure 3

From: Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis

Figure 3

BML-111 suppresses the expression of proteins related to RAGE and TLR4 signaling in IMQ-induced psoriasiform dermatitis in mice. Protein levels of RAGE (A,B), TLR4 (D,E), ERK1/2 and p-ERK1/2 (G,H), and nuclear NF-κB p65 (I,J) were analyzed by western blotting. Full-length blots are presented in Suppl. Figures S2–S5. mRNA levels of RAGE (C) and TLR4 (F) were analyzed in the three groups of mice. The results are shown as the mean ± SD. **p < 0.01 and *p < 0.05, compared to mice treated with IMQ. All experiments were conducted thrice, and the representative results are shown.

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