Figure 4 | Scientific Reports

Figure 4

From: Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis

Figure 4

BML-111 decreases the inflammatory cytokines expression in IMQ-induced psoriasiform dermatitis in mice. Real-time quantitative PCR was performed to analyze the mRNA expression of IL-1β (A), TNF-α (B), IFN-γ (C), IL-6 (D), IL-17a (E), IL-17c (F), IL-23 (G), and IL-22 (H) in the skin biopsies from mice. The serum concentration of IL-1β (I), TNF-α (J), IL-17 (K) and IL-23 (L) in the collected serum on day 8 was determined by ELISA. The results are shown in mean ± SD. **p < 0.01 and *p < 0.05 when compared to mice treated with IMQ. All experiments were conducted thrice, and the representative results are shown.

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