Figure 5 | Scientific Reports

Figure 5

From: The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction

Figure 5

Postulated model showing the cardioprotective effects of TDAG8-expressing cardiac macrophages against MI. MI induces a pH reduction and severe inflammation at infarcted areas. TDAG8 expressed on cardiac macrophages recognises extracellular pH changes and inhibits the Ccl20 transcription stimulated by inflammatory factors (e.g. HMGB1 and TNF-α), which inhibits the recruitment of IL-17A-producing CCR6+ γδT cells. These cells are mediators of cell death and fibrosis, thus explaining the cardioprotective effects of TDAG8.

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