Figure 4

MiR-98 overexpression inhibits the expression of Fas and caspase-3. (A) and (B) MiR-98 overexpression significantly prevented upregulation of Fas mRNA and protein level in H₂O₂-treated NRVCs. Cropped blots are shown. Full-length blots are presented in Supplementary Fig. S3. n = 5. (C) and (D) The mRNA and protein expression of caspase-3 were also remarkably elevated by H₂O₂ but reduced by miR-98 overexpression. Cropped blots are shown. Full-length blots are presented in Supplementary Fig. S4. n = 6. *P < 0.05, **P < 0.01 versus control; ^# P < 0.05, ^## P < 0.01 versus H₂O₂ + NC cells.