Figure 4

Differential expression of genes involved in membrane excitability and cardiac conduction. Genes relevant to these categories were identified by Gene Ontology analyses. RPKM values for WT (black bars) and AE3-null (white bars) hearts are shown. See Supplementary Information for detailed explanations and references for individual genes. The genes shown are a subset of 104 genes presented in Supplementary Table S5 and 84 transporter, pump, and channel genes in Supplementary Table S6; values are means ± SE; n = 4 for each genotype; *p ≤ 0.01 vs WT controls, except Kcne1 (p = 0.015).