Table 1 Significantly enriched Gene Ontology (GO) categories.

From: RNA SEQ Analysis Indicates that the AE3 Cl−/HCO3 − Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart

GO Category

P-value

Enrichment

(N, B, n, b)

Hypoxia/Angiogenesis/Vasodilation

GO:0001525 Angiogenesis

8.08E-12

3.57

(21238,231,979,38)

GO:0001666 Response to hypoxia

7.5E-05

2.71

(21238,152,979,19)

GO:0019229 Regulation of vasoconstriction

6.51E-04

3.39

(21238,64,979,10)

GO:0042312 Regulation of vasodilation

7.86E-04

3.96

(21238,44,979,8)

Lipid/Carbohydrate metabolism

GO:0006109 Regulation of carbohydrate metabolic process

2.74E-07

8.79

(21239,151,176,11)

GO:0010906 Regulation of glucose metabolic process

6.16E-05

4.6

(21257,99,607,13)

GO:0008286 Insulin receptor signaling pathway

8.09E-05

6.52

(21257,49,599,9)

GO:0019216 Regulation of lipid metabolic process

1.11E-04

2.57

(21257,230,863,24)

GO:0032868 Response to Insulin

4.36E-04

3.84

(21257,120,599,13)

GO:0006110 Regulation of Glycolytic Process

3.48E-04

19.35

(21257,26,169,4)

Cardiac conduction/Transporters/Channels

GO:0008016 Regulation of heart contraction

3.76E-10

4.22

(21228,132,990,26)

GO:0061337 Cardiac conduction

2.22E-08

8.42

(21228,28,990,11)

GO:0002027 Regulation of heart rate

1.55E-08

5.21

(21228,70,990,17)

GO:0006811 Ion transport

3.56E-06

1.67

(21239,1054,990,82)

GO:0006813 Potassium ion transport

2.72E-05

2.82

(21239,152,990,20)

GO:0086001 Cardiac muscle cell action potential

1.89E-07

7.95

(21239,27,990,10)

GO:0051899 Membrane depolarization

1.59E-04

3.09

(21228,97,990,14)

GO:0086015 SA node cell action potential

3.9E-04

16.09

(21239,4,990,3)

GO:0086069 Bundle of His cell to Purkinje myocyte communication

4.9E-04

9.53

(21239,9,990,4)

GO:0086067 AV node cell to bundle of His cell communication

9.41E-04

12.87

(21239,5,990,3)

GO:0006816 Calcium ion transport

9.84E-04

2.17

(21239,198,990,20)

Sarcomere/Z-disc/Cytoskeleton

GO:0044449 Contractile fiber part

2.93E-14

4.57

(21238,166,979,35)

GO:0032432 Actin filament bundle

3.06E-11

6.54

(21238,63,979,19)

GO:0042641 Actomyosin

4.97E-09

5.59

(21238,66,979,17)

GO:0030018 Z disc

8.18E-09

4.62

(21238,94,979,20)

GO:0030315 T-tubule

2.19E-07

5.76

(21238,49,979,13)

GO:0014704 Intercalated disc

3.71E-05

4.72

(21238,46,979,10)

  1. GO categories were identified using the GOrilla program15 and grouped by related functions as described in Methods and Supplementary Information. The degree of enrichment = (b/n)/(B/N), with (N, B, n, b) defined as follows: N is the total number of genes, B is the total number of genes associated with a specific GO term, n is the number of genes in the target set, b is the number of genes in the intersection. For more complete information on GO categories and how to access specific gene lists in Excel Files, see legends for Supplementary Tables 2–7.
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