Figure 7
From: Shape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells
Schematic representation of the proposed cytotoxicity pathways for PLGA-PEG NPs with different morphological features. Upper panel: A spherical-shaped PLGA NP entered the cell via endocytosis, stably resided in the lysosomes, and had no apparent cytotoxicity. Lower panel: A needle-shaped PLGA NP entered the cell via endocytosis, resided in lysosomes and induced lysosomal membrane perturbation, caused caspase-3 activation and DNA damage, and finally apoptosis.
