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Figure 1

From: Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Figure 1

Ginkgolic and anacardic acid fail to suppress global SUMO-conjugation in human GBM lines. U251 (A), LN229 (B), and Mz18 (C), at concentrations of 10 μM or 100 μM. Representative immunoblots are shown. High molecular weight (>100 kDa) SUMO-1 and SUMO-2/3 conjugates were cropped in each lane and the total intensities were measured. Densitometries were normalized to corresponding actin levels and expressed as a fold difference relative to the control (DMSO). Data are means (±SD) from n = 3 independent experiments.

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