Figure 3 | Scientific Reports

Figure 3

From: Discovery of novel therapeutic properties of drugs from transcriptional responses based on multi-label classification

Figure 3

Global analysis of novel therapeutic property. (A) Pearson correlation coefficient of ER matrices with various DTN-T thresholds. (B) Heatmap of ER matrix indicating the repositioning potential between 14 therapeutic properties. ATC therapeutic properties include: A, alimentary tract and metabolism; B, blood and blood-forming organs; C, cardiovascular system; D, dermatologicals; G, genito-urinary system and sex hormones; H, systemic hormonal preparations, excluding sex hormones and insulins; J, anti-infectives for systemic use; L, anti-neoplastic and immunomodulating agents; M, musculoskeletal system; N, nervous system; P, anti-parasitic products; R, respiratory system; S, sensory organs; and V, several others. (C) Spearman correlation coefficient distribution of 247 drugs across DTN-T and DTN-SE. (D) Spearman correlation coefficient distribution of 247 drugs across DTN-T and DTN-ST.

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