Table 4 Proteins of Interest that Demonstrate a Difference in Expression between Survivors and Non-Survivors in Low Control.
Uniprot Accession Number | Protein Name | Non-survivors | Survivors | p-value | ||
|---|---|---|---|---|---|---|
N | Weighted log fold change (mean ± SE) | N | Weighted log fold change (mean ± SE) | |||
Metabolic enzymes | ||||||
P40394-2 | Isoform 2 of Alcohol dehydrogenase class 4 mu/sigma chain | 13 | 0.26 ± 0.09 | 17 | 1.74 ± 0.17 | 6.36E-06 |
Q04828 | Aldo-keto reductase family 1 member C1 | 13 | 0.15 ± 0.08 | 17 | 0.93 ± 0.12 | 3.54E-04 |
P22352 | Glutathione peroxidase 3 | 16 | 0.43 ± 0.08 | 20 | 1.15 ± 0.16 | 3.96E-03 |
P05091 | Aldehyde dehydrogenase, mitochondrial | 6 | 0.37 ± 0.04 | 6 | 1.19 ± 0.21 | 3.19E-02 |
P09210 | Glutathione-S-trasferase A2 | 15 | 0.70 ± 0.15 | 15 | 1.21 ± 0.18 | 0.08 |
Proteins mapped to fibrosis pathways | ||||||
P20908 | Collagen alpha-1 (V) chain | 12 | 0.39 ± 0.08 | 12 | 1.19 ± 0.16 | 4.04E-03 |
P22692 | Insulin-like growth factor binding protein 4 | 16 | 1.12 ± 0.14 | 20 | 0.52 ± 0.06 | 7.17E-03 |
P19320 | Vascular cell adhesion protein 1 | 13 | 0.58 ± 0.13 | 17 | 0.16 ± 0.05 | 2.73E-02 |
P02751 | Fibronectin | 16 | 0.00 ± 0.07 | 20 | 0.30 ± 0.09 | 3.73E-02 |
H7BXV5 | Collagen alpha-1 (XVIII) chain | 13 | 0.82 ± 0.12 | 17 | 0.37 ± 0.07 | 1.81E-02 |
Proteins with differential expression that also were identified in our previous study | ||||||
P11684 | Club cell secretory protein (uteroglobin) | 16 | 2.03 ± 0.11 | 20 | 0.43 ± 0.11 | 1.68E-09 |
P00450 | Ceruloplasmin | 16 | 0.17 ± 0.10 | 20 | 0.60 ± 0.09 | 1.90E-02 |
P00747 | Plasminogen | 16 | 0.24 ± 0.14 | 20 | 0.68 ± 0.14 | 6.77E-02 |
P15311| | Ezrin | 16 | 0.63 ± 0.12 | 20 | 0.32 ± 0.06 | 6.24E-02 |
P06702 | S100-A9 | 16 | 0.36 ± 0.13 | 20 | 0.76 ± 0.13 | 8.01E-02 |
P01008 | Antithrombin-III | 16 | 0.12 ± 0.12 | 20 | 0.35 ± 0.11 | 2.04E-01 |
P00748 | Coagulation factor XII | 16 | 0.19 ± 0.10 | 20 | 0.34 ± 0.08 | 2.66E-01 |
