Table 5 IPA Canonical Pathways Represented by Proteins Differentially Expressed Between Survivors and Non-Survivors.

From: Bronchoalveolar Lavage Fluid Protein Expression in Acute Respiratory Distress Syndrome Provides Insights into Pathways Activated in Subjects with Different Outcomes

Ingenuity Canonical Pathways

−log (B-H p-value)A

Gene Symbols

Protein Names

Complement System

1.34E01

C4A/C4B, CR1, CD55, MBL2, C1S, C9, MASP1, C8B, C6, C1QB, CFH, C5

Complement C4-A/C4-B, Complement receptor type 1, complement decay-accelerating factor (CD antigen CD 55), Mannose-binding protein C, Complement C1s subcomponent, Complement component C9, Mannan-binding lectin serine protease 1, Complement component C8 beta, Complement component C6, Complement C1q subcomponent subunit B, Complement factor H, Complement C5

Acute Phase Response Signaling

7.41E00

ITIH3, FN1, C1S, C9, CP, SERPINA3, C5, SERPIND1, C4A/C4B, KLKB1, MBL2, ITIH4, CRP, AGT

Inter-alpha-trypsin inhibitor heavy chain H3, Fibronectin, Complement C1s subcomponent, Complement component C9, Ceruoplasmin, alpha-1-antichymotrypsin, Complement C5, Heparin cofactor 2, Complement C4-A/C4-B, Plasma kallikrein, Mannose-binding protein C, Inter-alpha = trypsin inhibitor heavy chain H4, C-reactive protein, Angiotensinogen

Ethanol Degradation II

6.41E00

ALDH2, AKR1A1, ADH7, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase class 4 mu/sigma, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Tryptophan Degradation X (Mammalian, via Tryptamine)

6.41E00

ALDH2, AKR1A1, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Aldo-keto reductase family 1 member A1, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Noradrenaline and Adrenaline Degradation

6.24E00

ALDH2, AKR1A1, ADH7, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase class 4 mu/sigma, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

FXR/RXR Activation

6.24E00

C4A/C4B, KNG1, L CAT, ITIH4, C9, FBP1, PLTP, GC, A1BG, CLU, AGT

Complement C4-A/C4-B, Kininogen-1,, Lecithin-cholesterol acyltransferase, Inter-alpha = trypsin inhibitor heavy chain H4, Complement component C9, Fructose-1 6-bisphosphatase 1, Phospholipid transfer protein, Vitamin D-binding protein, Alpha-1B-glycoprotin, Clusterin, Angiotensinogen

Histamine Degradation

5.74E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

LXR/RXR Activation

5.49E00

C4A/C4B, KNG1, LCAT, ITIH4, C9, PLTP, GC, A1BG, CLU, AGT

Complement C4-A/C4-B, Kininogen-1, Lecithin-cholesterol acyltransferase, Inter-alpha = trypsin inhibitor heavy chain H4, Complement component C9, Fructose-1 6-bisphosphatase 1, Phospholipid transfer protein, Vitamin D-binding protein, Alpha-1B-glycoprotin, Clusterin, Angiotensinogen

Oxidative Ethanol Degradation III

5.49E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Fatty Acid α-oxidation

5.38E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Putrescine Degradation III

5.27E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Ethanol Degradation IV

5.04E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Serotonin Degradation

5E00

ALDH2, AKR1A1, ADH7, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase class 4 mu/sigma, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Dopamine Degradation

4.76E00

ALDH2, ALDH1A1, ALDH3B1, ALDH3A1, ALDH9A1

Aldehyde dehydrogenase mitochondrial, Retinal dehydrogenase 1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Methylglyoxal Degradation III

4.61E00

AKR1A1, AKR1C1/AKR1C2, AKR1C3, AKR1B10

Aldo-keto reductase family 1 member A1, C1/C2, C3, and B10

Intrinsic Prothrombin Activation Pathway

4.27E00

KNG1, KLKB1, F9, F5, COL18A1

Kininogen-1, Plasma kallikrein, Coagulation factor IX, V, Collagen alpha-1(XVIII)

Coagulation System

3.8E00

KNG1, KLKB1, F9, F5, SERPIND1

Kininogen-1, Plasma kallikrein, Coagulation factor IX, V, Heparin cofactor 2

Retinoate Biosynthesis I

2.83E00

ADH7, ALDH1A1, AKR1C3, AKR1B10

Alcohol dehydrogenase class 4 mu/sigma, Retinal dehydrogenase 1, Aldo-keto reductase family 1 member C3, B10

Aryl Hydrocarbon Receptor Signaling

2.65E00

TGM2, CTSD, ALDH1A1, NQO1, ALDH3B1, ALDH3A1, ALDH9A1

Protein-glutamine gamma-glutamyltransferase 2, Cathespin D, Retinal dehydrogenase 1, NAD(P)H dehydrogenase [quinone] 1, Aldehyde dehydrogenase family 3 member B1, A1, 4-trimethylaminobutyraldehyde dehydrogenase

Glycolysis I

1.94E00

FBP1, GAPDH, ALDOC

Fructose-1 6-bisphosphatase 1, Glyceraldehyde-3-phosphate dehydrogenase, Fructose-bisphosphate aldolase C

Gluconeogenesis I

1.91E00

FBP1, GAPDH, ALDOC

Fructose-1 6-bisphosphatase 1, Glyceraldehyde-3-phosphate dehydrogenase, Fructose-bisphosphate aldolase C

LPS/IL-1 Mediated Inhibition of RXR Function

1.62E00

ALDH1A1, FABP4, ALDH3B1, FABP5, PLTP, ALDH3A1, ALDH9A1

Retinal dehydrogenase 1, Fatty acid-binding protein adipocyte, Aldehyde dehydrogenase family 3 member B1, Fatty acid-binding protein epidermal, Phospholipid transfer protein, Aldehyde dehydrogenase dimeric NADP-preferring, 4-trimethylaminobutyraldehyde dehydrogenase

Atherosclerosis Signaling

1.41E00

VCAM1, L CAT, COL18A1, CLU, PRDX6

Vascular cell adhesion protein 1, Lecithin-cholesterol acyltransferase, Collagen alpha-1(XVIII), Clusterin, Peroxiredoxin-6

Neuroprotective Role of THOP1 in Alzheimer’s Disease

1.37E00

KNG1, SERPINA3, AGT

Kininogen-1, Alpha-1-antichymotrypsin, Angiotensinogen

Bile Acid Biosynthesis, Neutral Pathway

1.37E00

AKR1C1/AKR1C2, AKR1C3

Aldo-keto reductase family 1 member A1, C1/C2, C3

Hepatic Fibrosis/Hepatic Stellate Cell Activation

1.36E00

COL5A1, IGFBP4, VCAM1, FN1, COL18A1, AGT

Collagen alpha1-(V), Insulin-like growth factor binding protein 4, Vascular cell adhesion protein 1, Fibronectin, Collagen alpha-1(XVIII), Angiotensinogen

Colanic Acid Building Blocks Biosynthesis

1.34E00

TSTA3, UGP2

GDP-L-fucose synthase, UTP—glucose-1-phosphate uridylytransferase

  1. AThreshold for significance is -log (B-H) p-value ≥ 1.3, which is equivalent to a corrected p-value ≤ 0.05.
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