Table 1 Performance of APACHE IV, SAPS 3, APACHE II, MELD-Na, MELD, and CTP models on prediction of in-hospital mortality.

	APACHE IV -LT specific predicted mortality	SAPS 3	APACHE II	MELD-Na	MELD	CTP
AUC (95% CI)	0.91 (0.86–0.96)	0.78 (0.66–0.90)^*	0.81 (0.70–0.92)	0.74 (0.57–0.86)^†	0.76 (0.64–0.89)	0.68 (0.54–0.81)^‡
Cutoff point	54	56	20	22	21	10
H-L C-test χ²	6.70	5.47	6.78	5.96	11.99	4.48
p-value	0.57	0.71	0.56	0.65	0.15	0.48
H-L H-test χ²	7.35	9.42	6.85	2.00	5.63	3.9
p-value	0.50	0.31	0.55	0.98	0.69	0.87
SMR (95% CI)	NA	0.13 (0.08–0.21)	0.10 (0.06–0.16)	NA	NA	NA
Sensitivity	0.83	0.76	0.71	0.76	0.71	0.65
Specificity	0.84	0.70	0.86	0.66	0.79	0.60
PPV	0.13	0.07	0.13	0.06	0.09	0.05
NPV	0.99	0.99	0.99	0.99	0.99	0.98

Statistical comparison of APACHE IV-LT specific predicted mortality with ^*SAPS 3 scores (p = 0.012), ^†MELD-Na scores (p = 0.012), and ^‡CTP scores (p = 0.009) after Holm adjustment for multiple comparisons.
APACHE, acute physiology and chronic health evaluation; SAPS, Simplified Acute Physiology Score; LT, liver transplantation, MELD, model for end-stage liver disease; MELD-Na, model for end-stage liver disease-Na; CTP, Child-Turcotte-Pugh score; AUC, area under the receiver operating curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; H-L C-test. Hosmer-Lemeshow C-statistics; H-L H-test, Hosmer-Lemeshow H-statistics; NA, not applicable; SMR, Standardized mortality ratio.

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