Table 4 Factors associated with in-hospital mortality after liver transplantation.

From: Comparison of APACHE IV with APACHE II, SAPS 3, MELD, MELD-Na, and CTP scores in predicting mortality after liver transplantation

Variables

Unadjusted OR (95% CI)

P- value in univariable- analysis

Adjusted OR† (95% CI)

P- value in multivariable- analysis

Age

1.053 (0.994–1.116)

0.079

  

Gender (female)

0.742 (0.238–2.308)

0.606

  

Body mass index (kg/m2)

1.003 (0.974–1.033)

0.834

  

Initial Diagnosis

    

Hepatocellular carcinoma

0.718 (0.273–1.887)

0.501

  

Liver cirrhosis

 Hepatitis B virus LC

0.576 (0.219–1.516)

0.264

  

 Hepatitis C virus LC

1.940 (0.541–6.953)

0.309

  

 Alcoholic LC

1.401 (0.393–4.990)

0.603

  

 Others

0.961 (0.124–7.455)

0.969

  

Preoperative corrected sodium

1.087 (0.992–1.191)

0.073

1.142 (1.013–1.287)

0.029

MELD score

1.090 (1.046–1.136)

<0.001

  

Coexisting conditions

 Diabetes

1.008 (0.323–3.143)

0.989

  

 Hypertension

1.052 (0.297–3.729)

0.938

  

 Chronic kidney disease

1.217 (0.256–9.504)

0.852

  

Preoperative RRT

6.248 (1.656–23.581)

0.007

6.962 (1.154–42.004)

0.025

Perioperative factors

 Donor status (deceased)

4.457 (1.622–12.248)

0.004

  

 Recipient operation time (min)

0.998 (0.993–1.004)

0.492

  

 Intraoperative RBC (units)

1.015 (0.967–1.065)

0.229

  

Postoperative factor

 APACHE IV-LT specific predicted mortality*

1.069 (1.043–1.096)

<0.001

1.062 (1.033–1.093)

<0.001

 Inotropic support on admission to ICU

7.285 (2.415–21.979)

0.001

  

 Postoperative AKI

20.935 (6.655–65.858)

<0.001

  

 Postoperative RRT

45.757 (14.230–147.127)

<0.001

17.544 (4.778–64.418)

<0.001

 Biliary complication

1.253 (0.279–5.625)

0.768

  

 Reoperation

2.400 (0.760–7.580)

0.136

  

 Postoperative RBC (units)

1.041 (1.008–1.076)

<0.001

  

 Surgical site infection

10.213 (3.529–29.554)

<0.001

  

 ICU readmission

10.617 (3.661–30.790)

<0.001

8.070 (1.700–38.301)

0.009

 Preoperative hospital LOS

1.043 (1.017–1.070)

0.001

  
  1. p-value of Hosmer-Lemeshow goodness-of-fit test of multivariable analysis: 0.982. Nigelkerke R2: 0.604.
  2. *APACHE IV-LT specific predicted mortality which has the highest AUC was chosen as a representative variable among other scoring systems for multivariable analysis.
  3. †After adjusting for MELD score, donor status, vasopressors on admission, reoperation, postoperative RBC transfusion, surgical site infection, and preoperative hospital stay.
  4. LC, liver cirrhosis; MELD, model for end-stage liver disease; MELD-Na, model for end-stage liver disease-Na; APACHE, acute physiology and chronic health evaluation; SAPS, Simplified Acute Physiology Score; CTP, Child-Turcotte-Pugh score; AKI, acute kidney injury; RRT, renal replacement therapy; ICU, intensive care unit; LOS, length of stay.
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